Connecticut is in and Houston is out on the No. 1 line of the USA TODAY Sports latest bracketology after the Cougars fell 70-67 at Iowa State on Monday night.

The Huskies regained their grip on a No. 1 seed after rebounding from a road loss to St. John’s with Big East wins against Butler and Georgetown. UConn joins Michigan, Arizona and Duke. This foursome has separated itself from the pack thanks to a combined 35-6 record in Quad 1 games.

It’s a big week coming up for Michigan, which travels to Purdue on Tuesday night and then plays Duke in Washington, D.C., this weekend.

Iowa State takes over as the top-rated No. 2 seed after notching a second high-profile Big 12 win in a row, following this past Saturday’s 74-56 victory against Kansas.

Houston’s drop is one of several in the updated bracket involving some of the biggest names in the Power Five.

The Jayhawks slip to a No. 3 seed after the Iowa State loss erases some of the good vibes stemming from a torrid eight-game run that included wins against the Cyclones, Brigham Young, Texas Tech and Arizona.

Three losses in four games sent Michigan State to the No. 4 line. While two of those setbacks came against the Wolverines and Wisconsin, the Spartans’ résumé is dinged by an ugly road loss to Minnesota. The Gophers are 4-10 in Big Ten play and are 86th in the NET rankings.

Georgia, UCLA, Ohio State, TCU.

New Mexico, California, Missouri, Santa Clara.

Multi-bid leagues: Big Ten (11), SEC (10), ACC (8) Big 12 (8), Big East (3), West Coast (2), Mountain West (2).

This article originally appeared on USA TODAY: March Madness Bracketology: NCAA Tournament projection sees UConn rise