Luka Doncic and the Lakers make the long trip to Inglewood to take on James Harden and the Clippers tonight.

The Lakers are coming off a 115-107 win in Denver Tuesday night against the Nuggets. Doncic was dominant scoring 38, pulling down 13 rebounds and handing out 10 assists to lead LA to their second straight win. LeBron James added 19 points and Marcus Smart chipped in 15. The Clippers’ six-game winning streak was snapped Tuesday night when the Bulls routed them in Chicago, 138-110. It was the second half of a back-to-back for the Clips who could not overcome the absence of Kawhi Leonard (ankle/knee). James Harden had 24 points in the loss.

After starting the season 6-21, the Clippers are 13-3 in their last 16 games. That run has moved them from the cellar out West to tenth place and a spot in the play-in game. The Lakers are 5-5 in their last ten games but still sit tied for first with the surprising Phoenix Suns in the Pacific Division.

This matchup boils down to the Clippers’ commitment to defend against the Lakers’ offense. Over their last 16 games, the Clippers are allowing just 108 points per game. The Lakers do not play much defense but are efficient on offense averaging nearly 117 points per 100 possessions (No. 7 in the NBA).

This is the third meeting of the season between these teams. The Clippers took the most recent encounter, winning 103-88 on December 20. The Lakers outscored the Clips on November 25, 135-118.

Lets take a closer look at the matchup and take into consideration lineups, injuries, and other factors affecting the line and total.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch tipoff, odds courtesy of DraftKings recent team performance, player stats, and of course, our predictions, picks best bets for the game from our modeling tools and staff of experts.

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Game Details and How to Watch Live: Lakers at Clippers

• Date: Thursday, January 22, 2026
• Time: 10PM EST
• Site: Intuit Dome
• City: Inglewood, CA
• Network/Streaming: Amazon Prime Video

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Game Odds: Lakers vs. Clippers

The latest odds as of Thursday courtesy of DraftKings:

• Moneyline: Los Angeles Lakers (-108), Los Angeles Clippers (-112)
• Spread: Clippers -1.5
• Total: 223.5 points

This game opened Lakers -1.5 with the Total set at 223.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NBA schedule! 

Expected Starting Lineups: Lakers at Clippers

Lakers

• PG Luke Doncic
• SG Marcus Smart
• SF Jake LaRavia
• PF LeBron James
• C Deandre Ayton

Clippers

• PG James Harden
• SG Kris Dunn
• SF Kawhi Leonard
• PF John Collins
• C Ivica Zubac

Injury Report: Lakers at Clippers

Los Angeles Lakers

• Austin Reaves (calf) is listed as questionable for tonight’s game
• Adou Thiero (knee) is listed as questionable for tonight’s game

Los Angeles Clippers

• Kawhi Leonard (knee) is listed as questionable for tonight’s game
• Bogdan Bogdanovic (hamstring) is OUT for tonight’s game
• Derrick Jones (knee) is OUT for tonight’s game

Important stats, trends and insights: Lakers at Clippers

• The Clippers are 11-9 at home this season
• The Lakers are 14-8 on the road this season
• The Clippers are 20-23 ATS this season
• The Lakers are 23-19 ATS this season
• The OVER has cashed in 25 of the Lakers’ 42 games this season (25-17)
• The OVER has cashed in 21 of the Clippers’ 43 games this season (21-22)
• The season series is tied at 1 game apiece

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NBA calendar based on data points like recent performance, head-to-head player matchups, trends information and projected game totals.
 
Once the model is finished running, we put its projections next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for today’s Lakers and Clippers’ game:

• Moneyline: Rotoworld Bet is leaning towards a play on the Clippers on the Moneyline
• Spread: Rotoworld Bet is recommending a play on the Clippers -1.5
• Total: Rotoworld Bet is staying away from a play on the Game Total of 223.5

Want even more NBA best bets and predictions from our expert staff & tools? Check out the Expert NBA Predictions page from NBC Sports for money line, spread and over/under picks for every game on today’s calendar! 

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our NBA Top Trends tool on NBC Sports!

Follow our experts on socials to keep up with all the latest content from the staff: 

• Jay Croucher (@croucherJD)
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• Vaughn Dalzell (@VmoneySports) 
• Trysta Krick (@Trysta_Krick)