Iran's supreme leader Mojtaba Khamenei said Wednesday that anyone expecting a shift in U.S. policy was "seriously mistaken", hours after midterm elections dealt a blow to President Donald Trump.

"Those who still harbor even the slightest hope that the behavior of the hegemonic system might change through partisan or factional shifts, or who imagine that making concessions to the United States can dissuade it from hostility towards the Iranian nation, are seriously mistaken," Khamenei said in a written statement published on his website.